Tablets and minitablets prepared from spray-dried SMEDDS containing naproxen

Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal candidiasis.

The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by incorporating drug loaded microspheres and using bioadhesive polymers hydroxypropylmethylcellulose, sodium carboxymethylcellulose and Carbopol. Microsph...

Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L.)

Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect is mainly due to the presence of the sesquiterpene lactone parthenolide as well as of flavonoids. So far, there are no studies on standardization of pre-formulations or phytomedicines containing this herb. The present study aimed at developing a pre-for...

Sustained release matrix tablets prepared from cospray dried mixtures with starch hydrophobic esters.

In this work, starch acetate and propanoate derivatives with moderate degree of substitution were synthesized and characterized for employment as matrix formers for sustained release from tablets. Matrix tablets were prepared from cospray-dried and simple physical mixtures of starch/starch derivatives and theophylline as a model drug. The release was rapid for matrix tablets prepared from simpl...

Effect of lubricant content and drug type on spray-dried chitosan-clay composite tablets

Fujicalin® - Unique Spray Dried Carrier for Liquisolid Systems and Probiotic Tablets that Last 3 Years Introduction

Introduction Since the late 1950s and early 60’s, conventional calcium hydrogen phosphate has been widely used as the excipient for direct compression tabletting. However, the fi rst generation of calcium phosphates were hard and rough pillar-like crystals with crystal water, which often caused abrasiveness of punches and dies in tabletting. In addition, the crystal water could possibly be rele...